Hepatic SIRT1 controls several transcription factors that regulate glucose, lipid, and cholesterol homeostasis.5 Actually, liver-specific SIRT1 knockout mice develop hepatic steatosis,6 and extensive weight loss in obese patients increases sirtuin expression significantly in both adipose tissue and liver, probably as a consequence of reduced inflammation.7 Regarding inflammation, it has been described that NF-κB is a target of SIRT1. The gene discussed is SIRT1; the disease is fatty liver disease.