LGR5 and infectious otitis media: This is noteworthy because human embryonic stem cells (hESCs) have constitutively active Bax at the Golgi, and active Bax translocates from Golgi to mitochondria after DNA damage in a p53-dependent manner, triggering a rapid apoptotic response.19 To examine whether the increase in mRNA expression was accompanied by enhanced expression at the protein level, we quantified total Bax expression in Lgr5+ stem cells and differentiated cells in n-6 PUFA versus n-3 PUFA+curcumin-fed mice in the presence of AOM.