For example, it has been shown that nonsteroidal anti-inflammatory drugs (NSAIDs) can induce apoptosis in Lgr5+ stem cells and suppress adenoma formation in APCMin/+ mice.5 Long-term use of NSAIDs, in particular COX-2-specific inhibitors, is associated with side effects, which has stimulated the development of new targets and combination strategies for cancer chemoprevention.6 This evidence concerns the gene LGR5 and cancer.