LGR5 and malignant colon neoplasm: This is a critical area of research because long-lived Lgr5+ stem cells are responsible for maintaining and regenerating intestinal crypts.29 These novel findings demonstrate that Lgr5+ stem cells are uniquely responsive to external dietary cues following the induction of DNA damage during tumor initiation and progression, providing a therapeutic strategy for eliminating damaged stem cells and reducing colon cancer risk.