We have previously demonstrated that colonic Lgr5+ stem cells are highly impacted by AOM exposure, resulting in the promotion of apoptosis and induction of MGMT expression compared with differentiated cells during the first 12–24 h after AOM exposure.4 In this study, we extend these findings by demonstrating for the first time that n-3 PUFA+curcumin combination maximally promotes targeted apoptosis (Figure 2c) and the induction of MGMT expression in DNA-damaged Lgr5+ stem cells (Figure 3b). This evidence concerns the gene MGMT and infectious otitis media.