LGR5 and malignant colon neoplasm: The deletion of damaged Lgr5+ stem cells, the cells of origin of colon cancer,21 is a critical mechanism to prevent tumorigenesis in the intestine.5 As n-3 PUFA27 and curcumin28 promote apoptosis in 1,2-dimethylhydrazine or AOM-injected rats, we next investigated the synergistic effects of n-3 PUFA+curcumin on the Lgr5+ stem cell acute DNA damage response.