LGR5 and cancer: There is an impending chronic disease crisis in our country and it is predicted that if the current trends continue, the number of cancer cases diagnosed annually by 2050 is likely to double as a result of population aging.47 Heading off this escalating burden of age-related illnesses requires an emphasis on primary cancer prevention research and training in cancer-related lifestyle decisions, including diet and exercise.47 Here we describe the effect of beneficial dietary factors on DNA damage-induced responses in Lgr5+ stem cells in the colon.