PTPN11 and acute respiratory distress syndrome: In agreement with the result in the PHPS1-treated mice, the Shp2−/− mice in the ALI model were characterized by decreased pulmonary leukocyte infiltration (Figure 6a), lower levels of pro-inflammatory cytokines in the lungs (Figure 6b) and milder inflammation-associated alveolar damage (Figure 6c) compared with their littermates.