Previous study shows that NCOA3 acts as a transcriptional coactivator of NF-κB and upregulates NF-κB signaling in cancer cells.7 Activated NF-κB directly induces the transcription of Bcl-2 gene.28 Therefore, these results raised the possibility that NCOA3 enhanced the expression of Bcl-2 through NF-κB/Bcl-2 pathway. Here, NCOA3 is linked to cancer.