Previous in vitro and in vivo studies have reported sensitization of RIPK1-deficient cells to TNF-mediated apoptosis.27, 28 Liver expression of TNF-α, and of its receptors TNFR1/2, is rapidly induced in the ConA-induced hepatitis model (Figures 3a and c,Supplementary Figures 2A and 4A). Here, TNFRSF1A is linked to hepatitis A virus infection.