CD44 and neoplasm: Hyaluronan (HA) is the best characterized ligand of CD44(ref. 10) and CD44/HA interactions control differentiation, proliferation, survival and migration of cells thereby playing a major role in tumor progression and metastasis.11 Binding of high molecular weight HA to CD44 augments CXCL12-induced signaling and subsequent angiogenesis12 and HA binding to CD44 and subsequent interaction with neural Wiskott–Aldrich syndrome protein induces actin polymerization and EGFR activation.13