Consistently, depletion of SASH1 from A549 lung cancer cells (Supplementary Figure 1A) suppressed apoptosis (Supplementary Figure 1B), whereas the use of an alternative siRNA targeting SASH1 (GenePharma, Shanghai, China; Supplementary Figure 2A) also significantly suppressed apoptosis (Supplementary Figure 2B). Here, SASH1 is linked to lung carcinoma.