It has been reported that IL-1β is upregulated in the retinas of patient with AMD34 and is associated with the death of photoreceptors.37, 38, 39 One of the essential pathway of IL-1β secretion has been indicated as the activation of NLRP3 in macrophage/microglia in many neurodegenerative disease,31 so we next performed immunofluorescence analysis of retinal tissues to determine whether chronic blue light could cause the upregulation of NLRP3 and IL-1β in microglia activated in the retina. The gene discussed is IL1B; the disease is neurodegenerative disease.