The most widely studied cells related to NLRP3 inflammasome activation in ocular research were RPE cells,33, 34, 35, 36 ganglion cell,51 and corneal epithelia,52, 53, 54 whereas the role of microglia has not been fully stressed.55 It is suggested that RPE undergoing significant changes in structure and function may have a central role in AMD pathogenesis. Here, NLRP3 is linked to age-related macular degeneration.