The NLRP3 inflammasome is a multiprotein complex that recruits caspase-1 and mediates the production of interleukin-1 beta (IL-1β) in microglia.31, 32 More recently, in AMD pathogenesis, NLRP3 inflammasome was reported mainly activated in retinal pigment epithelium (RPE) cells.33, 34, 35, 36 However, important questions remain, such as whether inflammasome activation is involved in microglia in retina under chronic light exposure, whether this activation leads to light-induced retinopathy, and can the retinopathy be alleviated through impairment of microglia recruitment. Here, CASP1 is linked to retinal disorder.