A375 human melanoma cells were subjected to siRNA-mediated knockdown of human syntenin-1 and transfected with vectors encoding wild-type mouse syntenin-1 (STN), an interaction-defective mutant (V211) syntenin-1 or a dimerization-defective mutant (ΔC) syntenin-1. The gene discussed is SDCBP; the disease is melanoma.