Interestingly, as shown in Fig. 1 (IFN-α2, IFN-γ, IL-12, IL-15, IP-10 and TNF-α as a representative) and S1 (other 20 cytokines), during acute stage of infection, plasma cytokines FGF-2, GM-CSF, IFN-α2, IFN-γ, IL-1β, IL-1ra, IL-2, IL-6, IL-10, IP-10, IL-12-p70, TNF-α and VEGF had more positive changes in RDPs than those in SDP. Here, TNF is linked to infection.