Karachaliou et al. analyzed the mRNA level of ROR1 in 27 NSCLC patients from the EURTAC trial (clinicaltrials.gov NCT00446225) who harbored EGFR T790M mutation, and showed that high ROR1 expression significantly limits progression-free survival (PFS) in the erlotinib-treated patients but not in the chemotherapy-treated patients37. Here, EGFR is linked to non-small cell lung carcinoma.