Although the mRNA levels of all target genes were restored by exogenous Rela overexpression in a dose-dependent manner, Traf2, Birc2 and Birc3 were restored by the Rela adenovirus at 20 multiplicity of infection, whereas the restoration of Pik3r1, Adamts5 and Hif2a required an multiplicity of infection of 100 (Fig. 8c). The gene discussed is EPAS1; the disease is infection.