Furthermore, the blockade of RegIIIγ by RegIIIγ-neutralizing antibody decreased SHP-1 production but increased JNK2 phosphorylation in normal mice (Fig. 7e, Supplementary Fig. 8e) while the administration of RegIIIγ before wounding induced SHP-1 production but inhibited JNK2 phosphorylation in skin wounds of T1D mice (Fig. 7f, Supplementary Fig. 8f). This evidence concerns the gene NR0B2 and type 1 diabetes mellitus.