TNF and type 1 diabetes mellitus: In contrast to normal mice, the production of RegIIIγ and SHP-1 was decreased while the phosphorylation of JNK2 was increased in the skin wounds of T1D mice (Fig. 7d, Supplementary Fig. 8c), which was accompanied by increased production of TNF-α and IL-6 (Supplementary Fig. 8d).