REG3A and type 1 diabetes mellitus: To confirm that REG3A is related to impaired wound healing in diabetes, we evaluated a streptozotocin (STZ)-induced experimental type 1 diabetic (T1D) mouse model and found that both mRNA and protein of RegIIIγ, a mouse homologue of human REG3A, dramatically decreased in skin wounds of C57BL/6 T1D mice (Fig. 1c–e).