CXCR4 and neoplasm: Among them, C-X-C chemokine ligand 12 (CXCL12) and its receptor C-X-C chemokine receptor type 4 (CXCR4) seem to be involved in the development of several organs [11, 12], including kidney [13], and they are also related to tumor growth [14] and metastatic process in many types of cancer [15].