Altered kinase activity has been implicated in a range of cellular processes processes in neurons, including neurite outgrowth, protein translation, mitophagy and et al (Jaleel et al., 2007; Imai et al., 2008; Gillardon, 2009; Hsu et al., 2010; Zhu et al., 2013; Stafa et al., 2012; Ito et al., 2016), which may underlie the pathogenesis of LRRK2 mutations in PD. This evidence concerns the gene LRRK2 and Parkinson disease.