Disruption of the interaction between Asp109 and Arg120 during αB-crystallin homodimerization is predicted to be important in causing a myopathy.4 The HSPB1 p.Asp129Glu and αB-crystallin p.Asp109His substitutions correspond to the same α-crystallin domain aspartate residue (figure 2B). Here, HSPB1 is linked to myopathy.