The use of a signaling pathway of the Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2-antioxidant-responsive element (Keap1-Nrf2-ARE) in vivo and in vitro leads to the downregulation of OS and inflammation, activated by DMF which may protect the nervous tissue against subarachnoid hemorrhage induced brain injury in rats [147]. The gene discussed is NFE2L2; the disease is subarachnoid hemorrhage.