AGER and chronic myelogenous leukemia, BCR-ABL1 positive: The present study was designed to elucidate, in the first part, the level of serum pentosidine, CML, and soluble form of RAGE (sRAGE) in patients with metabolic syndrome and, in the second part, to investigate the effect of several drugs, in particular, metformin which is known by its antiglycation effect, on pentosidine, CML, and sRAGE levels in these patients.