On the other hand, the down-regulated DEGs were related to the immune system, suggesting an inactive immune regulation, e.g., GPR183, INHBA, PTPRC, PLEK, CD8A and IKZF1. UVB irradiation is responsible for inducing systemic immune suppression, which is an important contributor to skin cancer [35]. The gene discussed is CD8A; the disease is skin neoplasm.