The similar route leading to NFкB activation is conducted via RAGE (receptor for advanced glycation endproducts) which is a multiligand receptor expressed on macrophages, neurons, endothelial cells and a variety of tumor cells [35, 36] and TREM-1 (trigerring receptor expressed on myeloid cells 1) a member of the immunoglobulin superfamily which was found on monocytes and neutrophils [37]. This evidence concerns the gene TREM1 and neoplasm.