Taken together, these results revealed that TRPV1v3, which is the most stable TRPV1 5'UTR variants, is responsible for the TRPV1 expression in GBM and GSCs TRPV1+ samples, while the complete profile of TRPV1 variants expression was present in NB, NHA and HNPC samples, and with different expression levels in Grade I-III gliomas. This evidence concerns the gene TRPV1 and central nervous system cancer.