TET1 and Epstein-Barr virus infection: Here, we showed that TET2 could be downregulated in gastric epithelial cells via EBV transcripts and upregulation of human miRNAs targeting TET2. Other TET family genes are also of great interest since several comprehensive genomic analyses in gastric cancer revealed mutation of TET1 in microsatellite-stable gastric cancers [8], and TET1 was also downregulated by EBV infection (Figure 1).