To address the pathological role of MAFB in CRC cells, a loss of function assay was performed by infecting the CRC cell line, SW1116, and HCT116 cells (endogenous MAFB expression patterns shown in Supplementary Figure S1) with lentivirus containing either shRNA targeting MAFB (shRNA678/shRNA679) or scramble shRNA (SHC002). Here, MAFB is linked to colorectal carcinoma.