MAFB and multicentric carpo-tarsal osteolysis with or without nephropathy: MAFB aberrations often lead to disease; chromosomal translocations result in ectopic MAFB expression in human myeloma cells [11], domain-specific MAFB mutations cause multicentric carpotarsal osteolysis syndrome [12], and elevated MAFB expression was observed in acute myeloid leukemia blasts [13].