E2F3 and neuroblastoma: By using the aforementioned dataset, we further observed a relationship between neuroblastoma progression and increased expression of CDK6 (χ2 = 27.50, df = 1, p-value = 1.6e-07), DNMT3A (χ2 = 14.56, df =1, p-value = 1.4e-04), DNMT3B (χ2 = 12.21, df = 1, p-value =4.8e-04), and E2F3 (χ2 = 161.81, df = 1, p-value =4.5e-37).