To determine whether IL-6 contributed to the regulation of hepatic Ppara expression and ketogenesis, we infused recombinant IL-6 or PBS into non-tumor-bearing littermate mice for 72 hr, with the highest rate of infusion achieving plasma IL-6 levels comparable to those occurring in pre-cachectic and cachectic C26- and PDA-bearing mice (Figure 3C). Here, IL6 is linked to Patent ductus arteriosus.