In this study, we showed that pomegranate peel extract, a product that is normally considered as waste, is also a source of bioactive compounds that can reduce the accumulation of senile plaques, increase the expression of the neurotrophin BDNF, reduce the activity of the enzyme acetylcholinesterase, reduce lipid peroxidation and reduce the expression of the inflammatory cytokine TNF-α. This evidence concerns the gene TNF and Senile plaques.