IFNG and infection: We highlight that, regardless of clinical status, expression data from individuals exposed to L. infantum display positive regulations of pathways and gene modules related to "type I interferon signaling" when compared to uninfected individuals, suggesting that IFN-αβ might play important roles in infections with L. infantum. Although the role of IFN-γ in infections with Leishmania has been extensively explored, the function of type I interferon signaling is not clear [48].