AR and Hypertension: A functional variation in the androgen-receptor gene in boys showed a difference in BP and sympathetic modulation of the vasomotor tone.[33] In large cohort studies, the prevalence of hypertension is lower in premenopausal women, but the prevalence gradually increases and becomes equal to that of men in the postmenopausal period.[34] Thus, IAF accumulation is thought to have an effect on BP according to sex.