NMC is cytogenetically characterized by a reciprocal translocation of the NUT (nuclear protein in testis) gene on the long arm of chromosome 15, with BRD4 on chromosome 19p13.1 (t(15;19)(q14;p13.1)) or, in rare cases, with BRD3 on chromosome 9q34.2 (t(15;9)(q14;q34.2)), leading to BRD4-NUT or BRD3-NUT fusion protein production by NMC cells [28,106]. The gene discussed is BRD4; the disease is nut midline carcinoma.