Further, knockdown of BRD4-NUT in HCC2429 cells, an NMC cell line established from a t(15;19) BRD4-NUT translocation lung cancer patient [107], induces their transformation from spindle-shape mesenchymal morphology to squamous morphology, increased expression of cell differentiation markers, and a reduction in cellular proliferation rate [108]. Here, BRD4 is linked to lung cancer.