The overexpression of HMGA1 in MCF-7 breast cancer cells downregulates XPA transcription and thus increases UV sensitivity [17,40], whereas HIF-1α binding to the hypoxia response element (HRE) in the XPA promoter upregulates XPA expression approximately five-fold, implying that targeting HIF-1α may improve chemo-efficacy [18]. The gene discussed is XPA; the disease is breast cancer.