In a murine melanoma model, the administration of the anti-acid drug esomeprazole (contrasting tumor acidity through the inhibition of vATPase) can increase CD8+ T cell infiltrate in tumor lesions and significantly potentiate the therapeutic efficacy of a cancer vaccine or adoptive immunotherapy [97], supporting the improved onset of antitumor immune responses in buffered pH conditions [98]. This evidence concerns the gene CD8A and neoplasm.