Treatment of MDA-MB-231 breast tumor cells with apigenin (ranging from 2.5 to 10 μg/mL) led to a partial decrease in urokinase-plasminogen activator (uPA) expression and completely inhibited phorbol 12-myristate 13-acetate (PMA)-induced MMP-9 secretion [199]. This evidence concerns the gene PLAU and breast neoplasm.