AKT1 and leukemia: Park et al. [246] used a flavonoid extract from the peel of Korean Citrus aurantium L. and found it was able to induce cell cycle arrest and apoptosis in A549 lung cancer cells, while Han and collaborators [247] suggested that a crude methanol extract of Citrus aurantium L. peel should induce caspase-dependent apoptosis through the inhibition of Akt in U937 human leukemia cells.