CDK2 and colon adenocarcinoma: The inhibition of the activity of cyclin-dependent kinases 2 (Cdk2) and 4 (Cdk4), accompanied by an increase in Cdk inhibitors p21 and p27 seems to be the mechanism through which tangeretin arrests cell cycle progression at the G1 phase in colon adenocarcinoma COLO 205 cells [52].