TNFSF10 and lung cancer: Indeed, it has been observed that naringenin enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in TRAIL-resistant A549 human lung cancer cells by the upregulation of TRAIL receptor 5 (death receptor 5, DR5, also named TRAIL-R2)) without inhibition of cell growth in human normal lung fibroblast WI-38 cells [118].