Moreover, naringenin (50 μM) and other flavonoids, among which hesperetin and apigenin, produced a more than three-fold increase in mitoxantrone accumulation by inhibition of breast cancer resistance protein (BCRP; an ATP-binding cassette transporter conferring multidrug resistance to a number of important anti-cancer agents) in BCRP-overexpressing MCF-7 (breast cancer) and NCI-H460 (lung cancer) cells, whereas the glycoside form (naringin) had no significant effects [119]. The gene discussed is ABCG2; the disease is breast cancer.