In human glioblastoma U87 cells, quercetin blocked PMA-induced migration and invasion by inhibiting ERK-dependent COX-2 activation and MMP-9 activity [211], while in the DAOY medulloblastoma cell line, it reduced both Met-induced cell migration and HGF-mediated Akt activation [212]. The gene discussed is AKT1; the disease is glioblastoma.