Addressing the function of TGFBR3 in the tumor microenvironment could help us determine if the current data on TGFBR3 in tumor is context dependent and that the behavior of the tumor cell is modified/regulated by the extracellular TGFBR3 or shed/soluble TGFBR3. Previous work understanding the mechanisms and triggers for the shedding and creation of sTβRIII demonstrates the complexity of these paracrine mechanisms [35]. The gene discussed is TGFBR3; the disease is neoplasm.