TGFBR3 and ductal breast carcinoma in situ: Figure 1A,B shows significant relative loss of TGFBR3 in the invasive breast carcinoma stroma compared to the control stroma [4,26]. Interestingly, based on analysis of the Ma et al. dataset, it appears that this decrease in TGFBR3 occurs gradually during breast cancer progression as demonstrated by the control stroma, ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC) (Figure 1C) [27].