PLAU itself further contributed to numerous pathways in cooperation with a variety of other genes such as LDLR and BIK, BCL2-interacting killer (“DNA damage response (only ATM dependent)”), CTGF (“amb2 Integrin signaling”), E2F transcription factor 2 (E2F2), fibroblast growth factor receptor 3 (FGFR3) and HMOX1 (“MicroRNAs in cancer”). The gene discussed is HMOX1; the disease is cancer.