Animals treated with anti-CTLA-4 mAb and anti-OX40 mAb and vaccinated with anti-DEC-205 (dendritic and epithelial cells, 205 kDa)-HER2 (human epidermal growth factor receptor 2) had significantly improved survival in a mammary carcinoma model [67]. The gene discussed is CTLA4; the disease is breast carcinoma.