IL1B and neoplasm: Tumor cells are able to produce a variety of inflammatory mediators including granulocyte-macrophage colony-stimulating factor (GM-CSF), granulocyte colony-stimulating factor (G-CSF), macrophage colony-stimulating factor (M-CSF), stem cell factor (SCF), vascular endothelial growth factor (VEGF), TGF-β, tumor necrosis factor (TNF)-α, IL-1β, IL-6, and IL-10 [1,2,3,4,26,27].