Given that gene-gene interactions may play a key role in the development of MetS, we hypothesized that SNPs within the aforementioned genes including APOA5, APOC1, BRAP, BUD13, CETP, LIPA, LPL, PLCG1, and ZPR1 may contribute to the etiology of MetS and its individual components independently and/or through complex interactions. This evidence concerns the gene APOA5 and metabolic syndrome.