Although ZPR1 was not a key gene in the present study (that is, no association with MetS), Aung et al. identified a potential gene-gene interaction between the BUD13 and ZPR1 genes on the risk of hypercholesterolaemia and hypertriglyceridaemia in Chinese subjects using GMDR analyses29. The gene discussed is BUD13; the disease is hypertriglyceridemia.