Our replication study is the first study to date to examine whether the main effects of the APOA5, APOC1, BRAP, BUD13, CETP, LIPA, LPL, PLCG1, and ZPR1 genes are significantly associated with the risk of MetS and its individual components independently and/or through gene-gene interactions among Taiwanese individuals. The gene discussed is APOC1; the disease is metabolic syndrome.