MITF and melanoma: We show here that a fully proficient FANC pathway is a key determinant for melanomagenesis ensuring the high proliferation and migration capabilities that characterize melanomas overexpressing the transcription factor microphthalmia (MiTF), which is amplified and/or mutated in a subset of patients with malignant melanoma where it acts as an oncogene12, 13, 14, 15.