DR5 mRNA expression was found significantly elevated in both KRAS mutant and KRAS wild-type CRC tissues with greater significance in KRAS mutant (KRAS-G13D, KRAS-G12D, KRAS-G12V) ones (p = 0.0006 for both) compared to normal pairs (Fig. 4A). This evidence concerns the gene KRAS and colorectal carcinoma.