TNFRSF10A and colorectal carcinoma: DR4 (TRAIL-R1) mRNA expression was also elevated in CRC (mean ± SEM: 1.926 ± 0.13 fold expression units) compared to normal tissues (mean ± SEM: 1.661 ± 0.08 fold expression units) (Table 1), but not in a statistically significant manner (p = 0.548), as calculated by the Wilcoxon Signed Ranks test (Table 2).