BIRC3 and colorectal carcinoma: Similarly, cIAP2 gene was found significantly down-regulated in CRC (mean ± SEM: 5.652 ± 0.53 fold expression units) compared to normal tissue (mean ± SEM: 9.208 ± 0.93 fold expression units) at the mRNA level (p < 0.0001), as calculated by the Wilcoxon Signed Ranks test (Tables 1 and 2).