BIRC5/Survivin over-expression has been reported to be involved in colorectal tumorigenesis by stimulating the transition of low-grade dysplasia adenomas into high dysplasia and CRC in situ and has been proposed as a biomarker with diagnostic and prognostic potential as well as a therapeutic target6, 27, 31. The gene discussed is BIRC5; the disease is colorectal carcinoma.