Interestingly, the role of the SOCE process, which is regulated in part by the ER-resident Stromal Interacting Molecule 1 (STIM1) and Calcium release-activated calcium channel protein 1 (Orai1), has been highlighted in the actomyosin contractility19, 20 and breast tumor cell migration21. Here, ORAI1 is linked to breast neoplasm.