Thus, CD8 TRM cells may divide the burden of patrolling peripheral tissues into two main tasks that are carried out by the epithelial and lamina propria subsets—one to limit spread of infection by directly eliminating infected cells, and the other to secrete IFN-γ to induce an antiviral state in select populations of local cells, in this case, the DRG neurons. The gene discussed is CD8A; the disease is infection.