Remarkably simultaneous knockdown of hepatic LCN13 and TSC22D4 expression by double adenoviral shRNA delivery (Supplementary Fig. 4g) partially re-induced systemic glucose intolerance (Fig. 4e) as well as dysfunctional glucose homeostasis and insulin resistance in diabetic mice (Fig. 4f,g). Here, OBP2A is linked to Insulin resistance.