In this regard, while acute TSC22D4 inactivation in tumour-bearing animals led to hypertriglyceridemia12, this effect was absent upon long-term TSC22D4 inhibition in diabetic animals, indicating that elevated systemic lipid levels either represent a more transient consequence of hepatic TSC22D4 deficiency and may not compromise the beneficial effects of TSC22D4 inactivation in the long run or only occur in the wild type but not in the diabetic situation. The gene discussed is TSC22D4; the disease is neoplasm.