In contrast to the induction of hypertriglyceridemia in cancer cachectic wild-type mice upon liver-specific TSC22D4 knockdown12, long-term TSC22D4 deficiency diminished serum triglycerides (TAGs) (Supplementary Fig. 3o) but left liver TAG levels unaltered (Supplementary Fig. 3p). This evidence concerns the gene TSC22D4 and hypertriglyceridemia.