In contrast, a reduction in tumour volume (percentage of tumour volume change relative to size at randomization) occurred with H446 VE-cadherin KD tumours following cisplatin/etoposide treatment (mean −43.4% reduction, median −47.9% reduction, range −9.4% to −68.1% reduction; Fig. 9a). The gene discussed is CDH5; the disease is neoplasm.