As this xenograft model system consists of a parental tumour where all cells express VE-cadherin and a VE-cadherin shRNA knockdown counterpart where all detectable VE-cadherin expression was lost (Fig. 7d), we were unable to assess whether there would be an enrichment of chemo-resistant VE-cadherin-positive cells following chemotherapy. Here, CDH5 is linked to neoplasm.