CDH5 and neoplasm: VE-cadherin KD cells grown as xenografts maintained a significant reduction in VE-cadherin expression (using the human-specific antibody) throughout the study (91.0 versus 1.5% of tumour cells stain for human VE-cadherin for H446 parental versus H446 VE-cadherin KD, P<0.0001; Fig. 7c,d, Supplementary Fig. 6).