In this study, we evaluated the antidiabetic activity of M. indica kernel flour (MIKF)‐supplemented diets in T2D rats, having reported in a recent study that MIKF is a rich source of pharmacologically important flavonoids and phenolic acids, and that its methanol extract inhibits some key enzymes (α‐amylase, α‐glucosidase, and aldose reductase) linked to the pathology and complications of T2D in vitro (Irondi et al. The gene discussed is AKR1B1; the disease is type 2 diabetes mellitus.