Among these 44 DE genes, we identified 12 genes with known association to RA (Figure 5C; Table S2 in Supplementary Material) due to their involvement in inflammatory processes, such as NF-kB activation (BCL10, MAP3K7/TAK1, MAPK1/ERK), inflammation (ALOX15, MAPK1/ERK, ATG3, ATXN3, VCL), induction of differentiation and/or activation of Th17 cells (BCL10, CD200R1), as well as chemotaxis and cellular infiltration of synovia (CCR2, CD200R1, SPN/CD43) (36–40). The gene discussed is SPN; the disease is rheumatoid arthritis.