In general, PI3K blockage and reduction in phosphorylated AKT level were observed in only a portion of tumor biopsies analyzed (Dolly et al., 2010; Wagner et al., 2011; Mahadevan et al., 2012; Markman et al., 2012; Britten et al., 2014; Papadopoulos et al., 2014; Yokota et al., 2014; Bendell et al., 2015b; Papadopoulos et al., 2015; Munster et al., 2016). This evidence concerns the gene AKT1 and neoplasm.