Insulin resistance (IR) is typified by a decrease in the sensitivity of insulin responsive cells such as myocytes, adipocytes, hepatocytes, and pancreatic β-cells to normal circulating levels of insulin which can in turn be manifested as impair glucose tolerance and subsequently type 2 diabetes (Sesti, 2006; Bruce and Hanson, 2010). The gene discussed is INS; the disease is type 2 diabetes mellitus.