MTOR and cancer: Continuous daily use of high dose mTOR inhibitors such as rapamycin in organ transplant (Miles et al., 1998; Kasiske et al., 2003) or rapalogs in cancer treatment have resulted in IR, glucose intolerance, increase gluconeogenesis, and diabetes-like syndrome in a subset of patients (Pallet and Legendre, 2013; Sivendran et al., 2014).