In non-NDD diagnoses, overexpression of BRINP2 (FAM5b) or BRINP3 (FAM5c) has been implicated in cancer: BRINP2 is amplified in oral squamous cell carcinoma (Cha et al., 2011), and BRINP3 is overexpressed in pituitary adenomas (Shorts-Cary et al., 2007). This evidence concerns the gene BRINP2 and oral cavity squamous cell carcinoma.