Further corroborating the involvement of these nuclei in the orexigenic drive under conditions of activity-based anorexia, a previous study reported a robust upregulation of orexigenic agouti-related peptide and neuropeptide Y, whereas the anorexigenic transmitters pro-opiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART) were reduced in the Arc of activity-based anorexia rats compared to sedentary food-restricted controls (de Rijke et al., 2005). The gene discussed is ARC; the disease is Anorexia.