FOS and Anorexia: It is to note that—although food intake was restricted to 1.5 g in the last feeding period before brain processing for Fos immunohistochemistry to avoid unspecific gastric distention and nauseating signals—a moderate activation of the area postrema, known to be involved in the mediation of nausea (Horn, 2014), has been observed in the activity-based anorexia but not in the ad libitum fed group.