PRNP and prion disease: Our previous study illustrates that flotilin-1 can mediate PrPC endocytosis in the cultured cells during Cu2+ stimulation through a molecular interaction.29 Further understanding of the contribution of the high brain level of mmu-miR-3473a during prion infection to flotillin-mediated PrPC endocytosis will help us further our knowledge of the physical biology and pathology of prion disease.