Pandina et al. (2012) reported 36 (9 %) prolactin-related adverse events, 14 cases (3.6 %) of gynecomastia/galactorrhea, 3 cases (1.0 %) of amenorrhea/dysmenorrhea, and a single case (<0.5 %) of impotence or decreased libido across study arms. This evidence concerns the gene PRL and amenorrhea.